I was inspiried by the international online Moodle conference (iMoot) and I am messing around with MySchool to add more information and make it look better. I put some news feeds in the center of the main page. I think they look good, but they take up a lot of room and might slow down loading time.
I am also thinking about adding a facebook style bar at the bottom of the page (for messages, calendar, etc.). I might even go with some drop down menus on the front page. You can add comments with suggestions/feedback.